Interaction guides
Is it safe to take these together?
Plain-language answers about common medication and supplement combinations, based on FDA drug labels and NIH sources. For your full list of meds, supplements and peptides, check them all at once in the SafeMix app.
- Moderate: use with caution
Warfarin + Fish oil (omega-3)
Can you take fish oil with warfarin?
- Serious: usually avoid
Sertraline (Zoloft) + St. John's wort
Can you take St. John's wort with Zoloft or other SSRIs?
- Serious: usually avoid
Warfarin + Aspirin
Can you take aspirin with warfarin?
- Moderate: use with caution
Ibuprofen + Lisinopril
Can you take ibuprofen with lisinopril?
- Serious: usually avoid
Opioids (oxycodone, hydrocodone) + Benzodiazepines (Xanax, Klonopin)
Is it safe to take Xanax with oxycodone or other opioids?
- Serious: usually avoid
Sildenafil (Viagra) + Nitrates (nitroglycerin, isosorbide)
Can you take Viagra with nitroglycerin or other nitrates?
- Moderate: use with caution
Levothyroxine (Synthroid) + Calcium and iron supplements
Can you take calcium or iron with levothyroxine?
- Moderate: use with caution
Simvastatin and some statins + Grapefruit juice
Can you have grapefruit with statins?
- Moderate: use with caution
Ginkgo biloba + Blood thinners (warfarin, Eliquis, Plavix)
Is ginkgo safe with blood thinners?
- Moderate: use with caution
Turmeric (curcumin) + Blood thinners
Can you take turmeric with blood thinners?
- Serious: usually avoid
Tramadol + SSRIs (sertraline, fluoxetine)
Can you take tramadol with an SSRI antidepressant?
- Moderate: use with caution
Semaglutide (Ozempic, Wegovy) + Insulin or sulfonylureas
Can you take Ozempic with insulin?
- Serious: usually avoid
Lithium + NSAIDs (ibuprofen, naproxen)
Can you take ibuprofen with lithium?
- Moderate: use with caution
Ciprofloxacin (Cipro) + Antacids, calcium, iron, magnesium, zinc
Can you take Cipro with antacids or vitamins?
These guides are for education only and are not medical advice. Always talk to your pharmacist or prescriber before starting, stopping or changing a medication or supplement.