Can you take ibuprofen with lithium?
Also searched as: Advil, Motrin, Aleve
Short answer
Avoid it unless your prescriber approves and monitors you. NSAIDs can raise lithium levels into a toxic range.
Why it happens
NSAIDs reduce how quickly the kidneys clear lithium, so lithium builds up in the blood.
What to do
- Ask your prescriber or pharmacist before taking any NSAID.
- If an NSAID is approved, your lithium level may need checking.
- Acetaminophen is often the safer choice, but confirm with your care team.
Signs to watch for
- Shaky hands, nausea or diarrhea
- Confusion or unsteady walking
- Slurred speech
If symptoms are severe, call 911 or go to the nearest emergency room.
Sources
Last reviewed November 4, 2026. For education only, not medical advice. Talk to your pharmacist or prescriber before changing anything.
