Can you take ibuprofen with lisinopril?
Also searched as: Advil, Motrin, NSAID, ACE inhibitor, Zestril, Prinivil
Short answer
Occasional use may be okay for some people, but regular use can raise blood pressure and strain the kidneys. Ask your pharmacist before using it more than a day or two.
Why it happens
NSAIDs like ibuprofen can reduce the blood-pressure-lowering effect of ACE inhibitors and, together, can reduce kidney function, especially in older adults, people who are dehydrated, or people also taking a diuretic.
What to do
- Use the lowest dose for the shortest time, if your pharmacist says ibuprofen is okay for you.
- Stay hydrated.
- Ask whether acetaminophen (Tylenol) is a better choice for you.
Signs to watch for
- Swelling in legs or feet
- Peeing much less than usual
- Higher blood pressure readings
If symptoms are severe, call 911 or go to the nearest emergency room.
Sources
Last reviewed November 4, 2026. For education only, not medical advice. Talk to your pharmacist or prescriber before changing anything.
